【参考文献】

1.B.D.Ratner.New Ideas in Biomaterials Science—a Path to Engineered Biomaterials.Journal of Biomedical Materials Research，1993（27）：pp.837-850.

2.H.K.Kleinman，D.Philp，M.P.Hoffman.Role of the Extracellular Matrix in Morphogenesis.Current Opinion in Biotechnology，2003（14）：pp.526-532.

3.林红赛，王春仁，王志杰，张华.生物材料的细胞生物相容性评价方法的研究进展.中国医疗器械信息，2011（17）：10～14.

4.S.K.Bhatia，A.B.Yetter.Correlation of Visual in Vitro Cytotoxicity Ratings of Biomaterials with Quantitative in Vitro Cell Viability Measurements.Springer，2009.pp.35-39.

5.E.Borenfreund，J.Puerner，Cytotoxicity of Metals，Metal-Metal and Metal-Chelator Combinations Assayed in Vitro.Toxicology，1986（39）：pp.121-134.

6.D.A.Scudiero，R.H.Shoemaker，K.D.Paull，A.Monks，S.Tierney，T.H.Nofziger，M.J.Currens，D.Seniff，M.R.Boyd.Evaluation of a Soluble Tetrazolium/Formazan Assay for Cell Growth and Drug Sensitivity in Culture Using Human and Other Tumor Cell Lines.Cancer Research，1988（48）：pp.4827.

7.C.Klein，M.Wagner，C.Kirkpatrick，T.van Kooten.A New Quantitative Test Method for Cell Proliferation Based on Detection of the Ki-67 Protein.Journal of Materials Science：Materials in Medicine，2000（11）：pp.125-132.

8.H.Oshima，T.Hatayama，M.Nakamura.A Possibility for New Evaluating Method of Cytotoxicity by Using Heat Shock Protein Assay.Journal of Materials Science：Materials in Medicine，1997（8）：pp.143-147.

9.H.Oshima，M.Nakamura，K.Yasuda，N.Yamagishi，T.Hatayama.Stress Protein Assay for the Evaluation of Cytotoxicity of Dental Amalgam.Journal of Materials Science：Materials in Medicine，2004（15）：pp.1-5.

10.李瑞，王青山.生物材料生物相容性的评价方法和发展趋势.中国组织工程研究与临床康复，2011（15）：5471～5474.

11.赵敏芝，魏世成，纪建国.蛋白组学方法应用于生物医用材料生物学评价.国际生物医学工程杂志 ISTIC，2010（33）.

12.J.Xu，K.A.Khor，J.Sui，J.Zhang，T.L.Tan，W.N.Chen.Comparative Proteomics Profile of Osteoblasts Cultured on Dissimilar Hydroxyapatite Biomaterials：an iTRAQ-Coupled 2-D LC-MS/MS Analysis.Proteomics，2008（8）：pp.4249-4258.

13.S.T.Zuckerman，W.J.Kao.Effect of Surface-adsorbed Proteins and Phosphorylation Inhibitor AG18 on Intracellular Protein Expression in Adherent Macrophages.Biomaterials，2006（27）：pp.3745-3757.

14.D.L.M.Dinnes，H.Maral，S.M.Mahler，J.P.Santerre，R.S.Labow.Material Surfaces Affect the Protein Expression Patterns of Human Macrophages：a Proteomics Approach.Journal of Biomedical Materials Research Part A，2007（80）：pp.895-908.

15.J.K.Kim，E.A.Scott，D.L.Elbert.Proteomic Analysis of Protein Adsorption：Serum Amyloid P Adsorbs to Materials and Promotes Leukocyte Adhesion.Journal of Biomedical Materials Research Part A，2005（75）：pp.199-209.

16.陆炜炜.生物材料血液相容性研究进展.国外医学：生物医学工程分册，2002（25）：230～234.

17.P.Tengvall，A.Askendal，I.Lundström.Temporal Studies on the Deposition of Complement on Human Colostrum IgA and Serum IgG Immobilized on Methylated Silicon.Journal of Biomedical Materials Research，1997（35）：pp.81-92.

18.H.T.Spijker，R.Bos，H.J.Busscher，T.G.van Kooten，W.van Oeveren.Platelet Adhesion and Activation on a Shielded Plasma Gradient Prepared on Polyethylene.Biomaterials，2002（23）：pp.757-766.

19.T.G.van Kooten，H.T.Spijker，H.J.Busscher.Plasma-treated Polystyrene Surfaces：Model Surfaces for Studying Cell-Biomaterial Interactions.Biomaterials，2004（25）：pp.1735-1747.

20.I.Gancarz，G.Pozniak，M.Bryjak，A.Frankiewicz.Modification of Polysulfone Membranes.2.Plasma Graftingand Plasma Polymerization of Acrylic Acid.Acta Polymerica，1999（50）：pp.317-326.

21.Z.Ding，J.Chen，S.Gao，J.Chang，J.Zhang，E.Kang.Immobilization of Chitosan onto Poly-L-lactic Acid Film Surface by Plasma Graft Polymerization to Control the Morphology of Fibroblast and Liver Cells.Biomaterials，2004（25）：pp.1059-1067.

22.Y.Toyama，M.Ohgaki，S.Nakamura，K.Katayama，K.Yamashita.Conformation of Self-assembled Organic Layer on the Electrically Polarized Hydroxyapatite Ceramics in Nonaqueous Solution.Solid State Ionics，2002（151）：pp.159-163.

23.J.A.Hubbell.Bioactive Biomaterials.Current Opinion in Biotechnology，1999（10）：pp.123-129.

24.K.E.Healy.Molecular Engineering of Materials for Bioreactivity.Current Opinion in Solid State&Materials Science，1999（4）：pp.381-387.

25.S.Sakiyama-Elbert，J.Hubbell.Functional Biomaterials：Design of Novel Biomaterials.Annual Review of Materials Research，2001（31）：pp.183-201.

26.K.Anselme.Osteoblast Adhesion on Biomaterials.Biomaterials，2000（21）：pp.667-681.

27.H.Shin，S.Jo，A.G.Mikos.Modulation of Marrow Stromal Osteoblast Adhesion on Biomimetic Oligo［Poly（Ethylene Glycol）Fumarate］Hydrogels Modified with Arg-Gly-Asp Peptides and a Poly（Ethylene Glycol）Spacer.Journal of Biomedical Materials Research，2002（61）：pp.169-179.

28.J.L.West，J.A.Hubbell.Polymeric Biomaterials with Degradation Sites for Proteases Involved in Cell Migration.Macromolecules，1999（32）：pp.241-244.

29.Y.Suzuki，M.Tanihara，K.Suzuki，A.Saitou，W.Sufan，Y.Nishimura.Alginate Hydrogel Linked with Synthetic Oligopeptide Derived from BMP-2 Allows Ectopic Osteoinduction in Vivo.Journal of Biomedical Materials Research，2000（50）：pp.405-409.

30.M.J.Humphries，S.K.Akiyama，A.Komoriya，K.Olden，K.M.Yamada.Identification of an Alternatively Spliced Site in Human Plasma Fibronectin that Mediates Cell Type-specific Adhesion.The Journal of Cell Biology，1986（103）：pp.2637-2647.

31.M.D.Pierschbacher，E.Ruoslahti.Cell Attachment Activity of Fibronectin Can Be Duplicated by Small Synthetic Fragments of the Molecule.Nature，1984（309）：p.30.

32.E.Ruoslahti，M.D.Pierschbacher.New Perspectives in Cell Adhesion：RGD and Integrins.Science，1987（238）：pp.491-497.

33.H.Shin，S.Jo，A.G.Mikos.Biomimetic Materials for Tissue Engineering.Biomaterials，2003（24）：pp.4353-4364.

34.J.A.Hubbell，S.P.Massia，N.P.Desai，P.D.Drumheller.Endothelial Cell-selective Materials for Tissue Engineering in the Vascular Graft via a New Receptor.Nature Biotechnology，1991（9）：pp.568-572.

35.汪冰，丰伟悦，赵宇亮，邢更妹，柴之芳，王海芳，贾光.纳米材料生物效应及其毒理学研究进展.中国科学：B 辑，2005（35）：1～10.

36.J.Koziara，J.Oh，W.Akers，S.Ferraris，R.Mumper.Blood Compatibility of Cetyl Alcohol/Polysorbate-based Nanoparticles.Pharmaceutical Research，2005（22）：pp.1821-1828.

37.A.Mayer，M.Vadon，B.Rinner，A.Novak，R.Wintersteiger，E.Fröhlich.The Role of Nanoparticle Size in Hemocompatibility.Toxicology，2009（258）：pp.139-147.