［1］Chow KC，Lee CC，Lin TY，Shen WC，Wang JH，Peng CT，Lee CC. Congenital enterovirus 71 infection：a case study with virology and immunohistochemistry. Clin Infect Dis. 2000；31（2）：509-512.

［2］Wong KT. Emerging and re-emerging epidemic encephalitis：a tale of two viruses. Neuropathol Appl Neurobiol. 2000；26（4）：313-318.

［3］Chen CY，Chang YC，Huang CC，Lui CC，Lee KW，Huang SC. Acute flaccid paralysis in infants and young children with enterovirus 71 infection：MR imaging findings and clinical correlates. AJNR Am J Neuroradiol. 2001；22（1）：200-205.

［4］Yu P，Gao Z，Zong Y，Bao L，Xu L，Deng W，Li F，Lv Q，Gao Z，Xu Y，Yao Y，Qin C. Histopathological fectures and distribution of EV71 antigens and SCARB2 in human fatal cases and a mouse model of enterovirus 71 infection. Virus Res. 2014；189：121-132.

［5］Chang LY，Chang IS，Chen WJ，Huang YC，Chen GW，Shih SR，Juang JL，Shih HM，Hsiung CA，Lin TY，Huang LM. HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics. 2008；122（6）：1271-1276.

［6］Zheng XQ，Chen XQ，Gao Y，Fu M，Chen YP，Xu DP，Lin A，Yan WH. Elevation of human leukocyte antigen-G expression is associated with the severe encephalitis associated withneurogenic pulmonary edema caused by Enterovirus 71. Clin Exp Med. 2014；14（2）：161-167.

［7］Pang L，Gong X，Liu N，Xie G，Gao W，Kong G，Li X，Zhang J，Jin Y，Duan Z. A polymorphism in melanoma differentiation-associated gene 5 may be a risk factor for enterovirus 71 infection. Clin Microbiol Infect. 2014 Mar 13.

［8］Wong KT，Munisamy B，Ong KC，Kojima H，Noriyo N，Chua KB，Ong BB，Nagashima K. The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways. J Neuropathol Exp Neurol. 2008；67（2）：162-169.

［9］Xu LJ，Jiang T，Zhang FJ，Han JF，Liu J，Zhao H，Li XF，Liu RJ，Deng YQ，Wu XY，Zhu SY，Qin ED，Qin CF. Global transcriptomic analysis of human neuroblastoma cells in response to enterovirus type 71 infection. PLoS One. 2013；8（7）：e65948.

［10］Lui YL，Timms P，Hafner LM，Tan TL，Tan KH，Tan EL. Characterisation of enterovirus 71 replication kinetics in human colorectal cell line，HT29. Springerplus. 2013；2（1）：267.

［11］Yan JJ，Wang JR，Liu CC，Yang HB，Su IJ. An outbreak of enterovirus 71 infection in Taiwan 1998：a comprehensive pathological，virological，and molecular study on a case of fulminant encephalitis. J Clin Virol. 2000；17（1）：13-22.

［12］Ong KC，Badmanathan M，Devi S，Leong KL，Cardosa MJ，Wong KT. Pathologic characterization of a murine model of human enterovirus 71 encephalomyelitis. J Neuropathol Exp Neurol. 2008；67（6）：532-542.

［13］Xie J1，Jiao Y，Qiu Z，Li Q，Li T. Significant elevation of B cells at the acute stage in enterovirus 71-infected children with central nervous systeminvolvement. Scand J Infect Dis. 2010；42（11-12）：931-935.

［14］Liang CC，Sun MJ，Lei HY，Chen SH，Yu CK，Liu CC，Wang JR，Yeh TM. Human endothelial cell activation and apoptosis induced by enterovirus 71 infection. J Med Virol. 2004；74（4）：597-603.

［15］Lu JR，Lu WW，Lai JZ，Tsai FL，Wu SH，Lin CW，Kung SH. Calcium flux and calpain-mediated activation of the apoptosis-inducing factor contribute to enterovirus 71-induced apoptosis. J Gen Virol. 2013；94（Pt 7）：1477-1485.

［16］Patel KP，Bergelson JM. Receptors identified for hand，foot and mouth virus. Nat Med. 2009；15（7）：728-729.

［17］Yamayoshi S，Yamashita Y，Li J，Hanagata N，Minowa T，Takemura T，Koike S. Scavenger receptor B2 is a cellular receptor for enterovirus 71. Nat Med. 2009；15（7）：798-801.

［18］Lin JY，Shih SR. Cell and tissue tropism of enterovirus 71 and other enteroviruses infections. J Biomed Sci. 2014；21：18.

［19］Yamayoshi S，Iizuka S，Yamashita T，Minagawa H，Mizuta K，Okamoto M，Nishimura H，Sanjoh K，Katsushima N，Itagaki T，Nagai Y，Fujii K，Koike S. Human SCARB2-depengdent infection by coxsackievirus A7，A14，and A16 and enterovirus 71. J Virol. 2012；86（10）：5686-5696.

［20］Jiao XY，Guo L，Huang DY，Chang XL，Qiu QC. Distribution of EV71 receptors SCARB2 and PSGL-1 in human tissues. Virus Res. 2014；190：40-52.

［21］He Y，Ong KC，Gao Z，Zhao X，Anderson VM，McNutt MA，Wong KT，Lu M. Tonsillar crypt epithelium is an important extra-central nervous system site for viral replication in EV71 encephalomyelitis. Am J Pathol. 2014；184（3）：714-720.

［22］Yamayoshi S，Ohka S，Fujii K，Koike S. Functional comparison of SCARB2 and PSGL1 as receptors for enterovirus 71. J Virol. 2013；87（6）：3335-3347.

［23］Liu J，Dong W，Quan X，Ma C，Qin C，Zhang L. Transgenic expression of human P-selectin glycoprotein ligand-1 is not sufficient for enterovirus 71 infection in mice. Arch Virol. 2012；157（3）：539-543.

［24］Khong WX，Yan B，Yeo H，Tan EL，Lee JJ，Ng JK，Chow VT，Alonso S. A non-mouse-adapted enterovirus （EV71）strain exhibits neurotropism，canusing neurological manifestations in a novel mouse model of EV71 infection. J Virol. 2012；86（4）：2121-2131.

［25］Wang SM，Liu CC. Enterovirus 71：epidemiology，pathogenesis and management. Expert Rev Anti Infect T-her. 2009；7（6）：735-742.

［26］Wu JM，Wang JN，Tsai YC，Liu CC，Huang CC，Chen YJ，Yeh TF. Cardiopulmonary manifestations of fulminant enterovirus 71 infection. Pediatrics. 2002；109（2）：E26.

［27］董广宇，郭伟，陈建良.神经源性肺水肿研究现状.国外医学.神经病学神经外科学分册. 2004；31 （2）：170-172.

［28］曹振宇，刘伟国，杨小峰.重度颅脑损伤与神经源性肺水肿.浙江医学. 2004；26（5）：396-398.

［29］Pyeron AM. Respiratory failure in the neurological patient：the diagnosis of neurogenic pulmonary edema. J Neurosci Nurs. 2001；33（4）：203-207.

［30］Theodore J，Robin ED. Speculations on neurogenic pulmonary edema（NPE）. Am Rev Respir Dis. 1976；113 （4）：405-411.

［31］Fujii K，Nagata N，Sato Y，Ong KC，Wong KT，Yamayoshi S，Shimanuki M，Shitara H，Taya C，Koike S. Transgenic mouse model for the study of enterovirus 71 neuropathogenesis. Proc Natl Acad Sci U S A. 2013；110（36）：14753-14758.

［32］Wang SM，Lei HY，Huang KJ，Wu JM，Wang JR，Yu CK，Su IJ，Liu CC. Pathogenesis of enterovirus 71 brain stem encephalitis in pediatric patients：roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis. 2003；188（4）：564-570.

［33］Lin TY，Hsia SH，Huang YC，Wu CT，Chang LY. Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system. Clin Infect Dis. 2003；36（3）：269-274.

［34］黄学明，刘现红.神经源性肺水肿患者血浆内皮素-1水平变化及临床意义.中华现代内科学杂志. 2005；2（3）：257-258.

［35］段国贤，周开顺，胡永奇，等.内皮素-1在神经源性肺水肿中的作用.中国应用生理学杂志. 2004；20 （3）：268-271.

［36］段国贤，周开顺，胡永奇，等.肿瘤坏死因子-α在神经源性肺水肿中的作用.华北煤炭医学院学报. 2004；6（4）：421-422.

［37］石丽娟，董榕，张晓红，等.室旁核内组胺在神经源性肺水肿发病中的作用.临床神经病学杂志. 2005；18（2）：127-129.

［38］唐烽，龙明.重型颅脑损伤并神经源性肺水肿26例临床分析.哈尔滨医药. 2002；22（1）：10.

［39］Barklin A，Theodorsson E，Tyvold SS，Larsson A，Granfeldt A，Sloth E，Tonnesen E. Alteration of neuropeptides in the lung tissue correlates brain death-induced neurogenic edema. J Heart Lung Transplant. 2009；28 （7）：725-732.

［40］Hamdy O，Nishiwaki K，Yajima M，Murakami HO，Maekawa H，Moy RT，Shimada Y，Hotta Y，Ishikawa N. Presence and quantification of neuropeptide Y in pulmonary edema fluids in rats. Exp Lung Res. 2000；26 （3）：137-147.

［41］Hamdy O，Maekawa H，Shimada Y，Feng GG，Ishikawa N. Role of central nervous system nitric oxide in the development of neurogenic pulmonary edema in rats. Crit Care Med. 2001；29（6）：1222-1228.

［42］Sedy J，Zicha J，Kunes J，Hejcl A，Syková E. The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats：the effect of preventive interventions. Am J Physiol Regul Integr Comp Physiol. 2009；297（4）：R1111-1117.

［43］Levasseur JE，Patterson JL Jr，Garcia CI，Moskowitz MA，Choi SC，Kontos HA. Effect of neonatal capsaicin treatment on neurogenic pulmonary edema from fluid-percussion brain injury in the adult rat. J Neurosurg. 1993；78（4）：610-618.

［44］Chung CY，Chen CY，Lin SY，Chung YC，Chiu HY，Chi WK，Lin YL，Chiang BL，Chen WJ，Hu YC. Enterovirus 71 virus-like particle vaccine：improved production conditions for enhanced yield. Vaccine. 2010；28（43）：6951-6957.

［45］Ong KC，Devi S，Cardosa MJ，Wong KT. Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease. J Virol. 2010；84（1）：661-665.

［46］Xu J，Qian Y，Wang S，Serrano JM，Li W，Huang Z，Lu S. EV71：an emerging infectious disease vaccine target in the Far East？Vaccine. 2010；28（20）：3516-3521.

［47］Zhu Z，Zhu S，Guo X，Wang J，Wang D，Yan D，Tan X，Tang L，Zhu H，Yang Z，Jiang X，Ji Y，Zhang Y，Xu W. Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly incentral and southern China before large-scale outbreaks from 2008. Virol J. 2010；7：300.

［48］Rabenau HF，Richter M，Doerr HW. Hand，foot and mouth disease：seroprevalence of Coxsackie A16 and Enterovirus 71 in Germany. Med Microbiol Immunol. 2010；199（1）：45-51.

［49］Yang C，Deng C，Wan J，Zhu L，Leng Q. Neutralizing antibody response in the patients with hand，foot and mouth disease to enterovirus 71 and its clinical complications. Virol J. 2011；8：306.

［50］Hamaguchi T，Fujisawa H，Sakai K，Okino S，Kurosaki N，Nishimura Y，Shimizu H，Yamada M. Acute encephalitis caused by intrafamilial transmission of enterovirus 71 in adult. Emerg Infect Dis. 2008；14（5）：828-830.

［51］Wang J，Pu J，Huang H，Zhang Y，Liu L，et al. EV71-infected CD14 + cells modulate the immune activity of T lymphocytes in rhesus monkeys. Emerg Microbes Infect. 2013：2（7）：e44.

［52］Lei X，Liu X，Ma Y，Sun Z，Yang Y，Jin Q，He B，Wang J. The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses. J Virol. 2010；84（16）：8051-8061.

［53］Li S，Cai C，Feng J，Li X，Wang Y，Yang J，Chen Z. Peripheral T lymphocyte subset imbalances in children with enterovirus 71-induced hand，foot and mouth disease. Virus Res. 2014；180：84-91.

［54］Wang SM，Lei HY，Su LY，Wu JM，Yu CK，Wang JR，Liu CC. Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity. Clin Microbiol Infect. 2007；13（7）：677-682.

［55］Chang LY，Hsiung CA，Lu CY，Lin TY，Huang FY，Lai YH，Chiang YP，Chiang BL，Lee CY，Huang LM. Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71. Pediatr Res. 2006；60（4）：466-471.

［56］Wu TC，Wang YF，Lee YP，Wang JR，Liu CC，Wang SM，Lei HY，Su IJ，Yu CK. Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice. J Virol. 2007；81（19）：10310-10315.

［57］Griffiths MJ，Ooi MH，Wong SC，Mohan A，Podin Y，Perera D，Chieng CH，Tio PH，Cardosa MJ，Solomon T. In enterovirus 71 encephalitis with cardio-respiratory compromise，elevated interleukin 1β，interleukin 1 receptor antagonist，and granulocyte colony-stimulating factor levels are markers of poor prognosis. J Infect Dis. 2012；206（6）：881-892.

［58］Wang SM，Lei HY，Liu CC. Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis. Clin Dev Immunol. 2012；2012：876241.

［59］Sato M，Hosoya M，Honzumi K，Watanabe M，Ninomiya N，Shigeta S，Suzuki H. Cytokine and cellular inflammatory sequence in enteroviral meningitis. Pediatrics. 2003；112（5）：1103-1107.

［60］Weng KF，Chen LL，Huang PN，Shih SR. Neural pathogenesis of enterovirus 71 infection. Microbes Infect. 2010；12（7）：505-510.

［61］Zhang Y，Liu H，Wang L，Yang F，Hu Y，Ren X，Li G，Yang Y，Sun S，Li Y，Chen X，Li X，Jin Q. Comparative study of the cytokine/chemokine response in children with differing disease severity in enterovirus 71-induced hand，foot，and mouth disease. PLoS One. 2013；8（6）：e67430.

［62］Dubin PJ，Kolls JK. IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice. Am J Physiol Lung Cell Mol Physiol. 2007；292（2）：L519-528.

［63］Happel KI，Lockhart EA，Mason CM，Porretta E，Keoshkerian E，Odden AR，Nelson S，Ramsay AJ. Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs. Infect Immun. 2005；73（9）：5782-5788.

［64］Kim B，Sarangi PP，Azkur AK，Kaistha SD，Rouse BT. Enhanced viral immunoinflammatory lesions in mice lacking IL-23 responses. Microbes Infect. 2008；10（3）：302-312.

［65］Del Vecchio M，Bajetta E，Canova S，Lotze MT，Wesa A，Parmiani G，Anichini A. Interleukin-12：biological properties and clinical application. Clin Cancer Res. 2007；13（16）：4677-4685.

［66］Haraldsen G，Balogh J，Pollheimer J，Sponheim J，Küchler AM. Interleukin-33- cytokine of dual function or novel alarmin？Trends Immunol. 2009；30（5）：227-233.

［67］Liew FY，Pitman NI，McInnes IB. Disease-associated functions of IL-33：the new kid in the IL-1 family. Nat Rev Immunol. 2010；10（2）：103-110.

［68］Wang SM，Lei HY，Yu CK，Wang JR，Su IJ，Liu CC. Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis. J Infect Dis. 2008；198（7）：1002-1006.

［69］Puneet P，Moochhala S，Bhatia M. Chemokines in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2005；288（1）：L3-15.

［70］Wang SM，Lei HY，Huang MC，Su LY，Lin HC，Yu CK，Wang JL，Liu CC. Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis. J Clin Virol. 2006；37（1）：47-52.

［71］Lin TY，Hsia SH，Huang YC，Wu CT，Chang LY. Proinflamatory cytokine reactions in enterovirus 71 infections of the central nervous system. Clin Infect Dis. 2003；36（3）：269-274.

［72］Khong WX，Foo DG，Trasti SL，Tan EL，Alonso S. Sustained high level of interleukin-6 contribute contribute to the pathogenesis of enterovirus 71 in a neonate mouse model. J Virol. 2011；85（7）：3067-3076.

［73］Brockman MA，Kwon DS，Tighe DP，Pavlik DF，Rosato PC，Sela J，Porichis F，Le Gall S，Waring MT，Moss K， Jessen H，Pereyra F，Kavanagh DG，Walker BD，Kaufmann DE. IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood. 2009；114（2）：346-356.

［74］Naicker DD，Werner L，Kormuth E，Passmore JA，Mlisana K，Karim SA，Ndung＇u T. Interleukin-10 promoter polymorphisms influence HIV-1 susceptibility and primary HIV-1 pathogenesis. J Infect Dis. 2009；200（3）：448-452.

［75］Moore KW，de Waal Malefyt R，Coffman RL，O＇Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001；19：683-765.

［76］Crawley E，Kay R，Sillibourne J，Patel P，Hutchinson I，Woo P. Polymorphic haplotypes of the interleukin-10 5＇flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum. 1999；42（6）：1101-1108.

［77］Kube D，Platzer C，von Knethen A，Straub H，Bohlen H，Hafner M，Tesch H. Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt＇s lymphoma cell lines. Cytokine. 1995；7 （1）：1-7.

［78］Lazarus M，Hajeer AH，Turner D，Sinnott P，Worthington J，Ollier WE，HutchinsonⅣ. Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus. J Rheumatol. 1997；24（12）：2314-2317.

［79］de Vries JE. The role of IL-13 and its receptor in allergy and inflammatory responses. J Allergy Clin Immunol. 1998；102（2）：165-169.

［80］Brightling CE，Saha S，Hollins F. Interleukin-13：prospects for new treatments. Clin Exp Allergy. 2010；40 （1）：42-49.

［81］Wills-Karp M. Interleukin-13 in asthma pathogenesis. Immunol Rev. 2004；202：175-190.

［82］Huang SW，Lee YP，Hung YT，Lin CH，Chuang JI，Lei HY，Su IJ，Yu CK. Exogenous interleukin-6，interleukin-13，and interferon-γ provoke pulmonary abnormality with mild edema in enterovirus 71-infected mice. Respir Res. 2011；12：147.

［83］Severini C，Improta G，Falconieri-Erspamer G，Salvadori S，Erspamer V. The tachykinin peptide family. Pharmacol Rev. 2002；54（2）：285-322.

［84］Ambrosi A，Espinosa A，Wahren-Herlenius M. IL-17：a new actor in IFN-driven systemic autoimmune diseases. Eur J Immunol. 2012；42（9）：2274-2284.

［85］Zhang Y，Yang E，Pu J，Liu L，Che Y，Wang J，Liao Y，Wang L，Ding D，Zhao T，Ma N，Song M，Wang X，Shen D，Tang D，Huang H，Zhang Z，Chen D，Feng M，Li Q. The Gene Expression Profile of Peripheral Blood Mononuclear Cells from EV71-Infected Rhesus Infants and theSignificance in Viral Pathogenesis. PLoS One. 2014；9（1）：e83766.

［86］Cunin P，Caillon A，Corvaisier M，Garo E，Scotet M，Blanchard S，Delneste Y，Jeannin P. The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1β，IL-23，and TNF-like 1A expression by monocytes. J Immunol. 2011；186（7）：4175-4182.

［87］Hosoi T，Okuma Y，Nomura Y. Electrical stimulation of afferent vagus nerve induces IL-1 beta expression in the brain and activates HPA axis. Am J Physiol Regul Integr Comp Physiol. 2000；279（1）：R141-147.

［88］Borsody MK，Weiss JM. Alteration of locus coeruleus neuronal activity by interleukin-1 and the involvement of endogenous corticotropin-releasing hormone. Neuroimmunomodulation. 2002-2003；10（2）：101-121.

［89］Olsson T，Kelic S，Edlund C，Bakhiet M，Höjeberg B，van der Meide PH，Ljungdahl A，Kristensson K. Neuronal interferon-gamma immunoreactive molecule：bioactivities and purification. Eur J Immunol. 1994；24（2）：308-314.

［90］Martin S，Maruta K，Burkart V，Gillis S，Kolb H. IL-1 and IFN-gamma increase vascular permeability. Immunology. 1988；64（2）：301-305.

［91］Corada M，Mariotti M，Thurston G，Smith K，Kunkel R，Brockhaus M，Lampugnani MG，Martin-Padura I，Stoppacciaro A，Ruco L，McDonald DM，Ward PA，Dejana E. Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci U S A. 1999；96（17）：9815-9820.

［92］Bidwell J，Keen L，Gallagher G，Kimberly R，Huizinga T，McDermott MF，Oksenberg J，McNicholl J，Pociot F，Hardt C，D＇Alfonso S. Cytokine gene polymorphism in human disease：on-line databases，supplement 1. Genes Immun. 2001；2（2）：61-70.

［93］Hill AV. The immunogenetics of human infectious diseases. Annu Rev Immunol. 1998；16：593-617.

［94］Xie HY，Wang WL，Yao MY，Yu SF，Feng XN，Jin J，Jiang ZJ，Wu LM，Zheng SS. Polymorphisms in cytokine genes and their association with acute rejection and recurrence of hepatitis B in Chinese liver transplant recipients. Arch Med Res. 2008；39（4）：420-428.

［95］Miyazoe S，Hamasaki K，Nakata K，Kajiya Y，Kitajima K，Nakao K，Daikoku M，Yatsuhashi H，Koga M，Yano M，Eguchi K. Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus. Am J Gastroenterol. 2002；97（8）：2086-2092.

［96］Peng XM，Huang YS，Ma HH，Gu L，Xie QF，Gao ZL. Interleukin-10 promoter polymorphisms are associated with the mode and sequel of HBeAg seroconversion in patients with chronic hepatitis B virus infection. Liver Int. 2006；26（3）：326-333.

［97］Crawley E，Kay R，Sillibourne J，Patel P，Hutchinson I，Woo P. Polymorphic haplotypes of the interleukin-10 5＇flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum. 1999；42（6）：1101-1108.

［98］Tso HW，Ip WK，Chong WP，Tam CM，Chiang AK，Lau YL. Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese. Genes Immun. 2005；6（4）：358-363.

［99］Ben-Ari Z，Mor E，Papo O，Kfir B，Sulkes J，Tambur AR，Tur-Kaspa R，Klein T. Cytokine gene polymorphisms in patients infected with hepatitis B virus. Am J Gastroenterol. 2003；98（1）：144-150.

［100］Kerr JR，McCoy M，Burke B，Mattey DL，Pravica V，Hutchinson IV. Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection. J Clin Pathol. 2003；56（10）：725-727.

［101］Yang J，Zhao N，Su NL，Sun JL，Lv TG，Chen ZB. Association of interleukin 10 and interferon gamma gene polymorphisms with enterovirus 71 encephalitis inpatients with hand，foot and mouth disease. Scand J Infect Dis. 2012；44（6）：465-469.

［102］Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev. 2001；14（4）：778-809.

［103］Liu ML，Lee YP，Wang YF，Lei HY，Liu CC，Wang SM，Su IJ，Wang JR，Yeh TM，Chen SH，Yu CK. Type I interferons protect mice against enterovirus 71 infection. J Gen Virol. 2005；86（Pt 12）：3263-3269.

［104］Rot A，von Andrian UH. Chemokines in innate and adaptive host defense：basic chemokinese grammar for immune cells. Annu Rev Immunol. 2004；22：891-928.

［105］Wang SM，Lei HY，Yu CK，Wang JR，Su IJ，Liu CC. Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis. J Infect Dis. 2008；198（7）：1002-1006.

［106］Asensio VC，Campbell IL. Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis. J Virol. 1997；71（10）：7832-7840.

［107］Bossink AW，Paemen L，Jansen PM，Hack CE，Thijs LG，Van Damme J. Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. Blood. 1995；86（10）：3841-3847.

［108］Glabinski AR，Balasingam V，Tani M，Kunkel SL，Strieter RM，Yong VW，Ransohoff RM. Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. J Immunol. 1996；156（11）：4363-436

［109］Salazar-Mather TP，Hamilton TA，Biron CA. A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense. J Clin Invest. 2000；105（7）：985-993.

［110］Ghersa P，Gelati M，Colinge J，Feger G，Power C，Ghersa P，Gelati M，Colinge J，Feger G，Power C，Papoian R，Salmaggi A. MIG—differential gene expression in mouse brain endothelial cells. Neuroreport. 2002；13 （1）：9-14.

［111］Carter SL，Müller M，Manders PM，Campbell IL. Induction of the genes for Cxcl9 and Cxcl10 is dependent on IFN-gamma but shows differential cellular expression in experimental autoimmune encephalomyelitis and by astrocytes and microglia in vitro. Glia. 2007；55（16）：1728-1739.

［112］Salazar-Mather TP，Hamilton TA，Biron CA. A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense. J Clin Invest. 2000；105（7）：985-993.

［113］Zlotnik A，Yoshie O. Chemokines：a new classification system and their role in immunity. Immunity. 2000；12（2）：121-127.

［114］Kunkel SL，Standiford T，Kasahara K，Strieter RM. Interleukin-8（IL-8）：the major neutrophil chemotactic factor in the lung. Exp Lung Res. 1991；17（1）：17-23.

［115］Winter PM，Dung NM，Loan HT，Kneen R，Wills B，Thu le T，House D，White NJ，Farrar JJ，Hart CA，Solomon T. Proinflammatory cytokines and chemokines in humans with Japanese encephalitis. J Infect Dis. 2004；190（9）：1618-1626.

［116］Simmons CP，Thwaites GE，Quyen NT，Torok E，Hoang DM，Chau TT，Mai PP，Lan NT，Dung NH，Quy HT，Bang ND，Hien TT，Farrar J. Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis：diagnostic value and relationship to disease severity and outcome. J Immunol. 2006；176（3）：2007-2014.

［117］Mellergård P，Åneman O，Sjögren F，Säberg C，Hillman J. Differences in cerebral extracellular response of interleukin-1β，interleukin-6，and interleukin-10 after subarachnoid hemorrhage hemorrhage or severe head trauma in humans. Neurosurgery. 2011；68（1）：12-19.

［118］Wang W，Li W，Yang X，Zhang T，Wang Y，Zhong R，Jiao Y，Li T，Jiang T，Tian Y，Wu H. Interleukin-8 is elevated in severe hand，foot，and mouth disease. J Infect Dev Ctries. 2014；8（1）：94-100.

［119］Talavera D，Castillo AM，Dominguez MC，Gutierrez AE，Meza I. IL8 release，tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers. J Gen Virol. 2004；85（Pt 7）：1801-1813.

［120］Sekido N，Mukaida N，Harada A，Nakanishi I，Watanabe Y，Matsushima K. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature. 1993；365（6447）：654-657.

［121］Luppi F，Longo AM，de Boer WI，Rabe KF，Hiemstra PS. Interleukin-8 stimulates cell proliferation in nonsmall cell lung cancer through epidermal growth factor receptortransactivation. Lung Cancer. 2007；56（1）：25-33.

［122］Brown AS，Hooton J，Schaefer CA，Zhang H，Petkova E，Babulas V，Perrin M，Gorman JM，Susser ES. Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am J Psychiatry. 2004；161（5）：889-895.

［123］　Zhang Y，Wang L，Zhang M，Jin M，Bai C，Wang X. Potential mechanism of interleukin-8 production from lung cancer cells：an involvement of EGF-EGFR-PI3K-Akt-Erk pathway. J Cell Physiol. 2012；227（1）：35-43.

［124］Chang LY，Chang IS，Chen WJ，Huang YC，Chen GW，Shih SR，Juang JL，Shih HM，Hsiung CA，Lin TY，Huang LM. HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics. 2008；122 （6）：1271-1276.

［125］Lin YW，Chang KC，Kao CM，Chang SP，Tung YY，Chen SH. Lymphocyte and antibody responses reduce enterovirus 71 lethality in mice by decreasing tissue viral loads. J Virol. 2009；83（13）：6477-6483.

［126］Chang LY，Hsiung CA，Lu CY，Lin TY，Huang FY，Lai YH，Chiang YP，Chiang BL，Lee CY，Huang LM. Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71. Pediatr Res. 2006；60（4）：466-471.

［127］Zeng M，Zheng X，Wei R，Zhang N，Zhu K，Xu B，Yang CH，Yang CF，Deng C，Pu D，Wang X，Altmeyer R，Leng Q. The cytokine and chemokine profiles in patients with hand，foot and mouth disease of different severities inShanghai，China，2010. PLoS Negl Trop Dis. 2013；7（12）：e2599.

［128］Loetscher M，Gerber B，Loetscher P，Jones SA，Piali L，Clark-Lewis I，Baggiolini M，Moser B. Chemokine receptor specific for IP10 and mig：structure，function，and expression in activated T-lymphocytes. J Exp Med. 1996；184（3）：963-969.

［129］Wei R，Yang C，Zeng M，Terry F，Zhu K，Yang C，Altmeyer R，Martin W，De Groot AS，Leng Q. A dominant EV71-specific CD4 + T cell epitope is highly conserved among human enteroviruses. PLoS One. 2012；7 （12）：e51957.

［130］Wei R，Xu L，Zhang N，Zhu K，Yang J，Yang C，Deng C，Zhu Z，De Groot AS，Altmeyer R，Zeng M，Leng Q. Elevated antigen-specific Th1 type response is associated with the poor prognosis of hand，foot and mouthdisease. Virus Res. 2013；177（1）：62-65.

［131］Lin TY，Chang LY，Huang YC，Hsu KH，Chiu CH，Yang KD. Different proinflammatory reactions in fatal and non-fatal enterovirus 71 infections：implications for early recognition and therapy. Acta Paediatr. 2002；91 （6）：632-635.

［132］Deng L，Jia HL，Liu CW，Xu YF，Mao LJ，He CH，Yin GQ，Lin JH，Tao JP，Zhu L. Proteomic analysis of extremely severe hand，foot and mouth disease infected by enterovirus 71. BMC Infect Dis. 2013；13：383.

［133］Ricklin D，Hajishengallis G，Yang K，Lambris JD. Complement：a key system for immune surveillance and homeostasis. Nat Immunol. 2010；11（9）：785-797.

［134］Zhang C，Xu Y，Jia L，Yang Y，Wang Y，Sun Y，Huang L，Qiao F，Tomlinson S，Liu X，Zhou Y，Song H. A new therapeutic strategy for lung tissue injury induced by influenza with CR2 targeting complement inhibitor. Virol J. 2010；7：30.

［135］Crack PJ，Taylor JM，Flentjar NJ，De Haan J，Hertzog P，Iannello RC，Kola I. Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1（Gpx-1）knockout mouse brain in response to ischemia/ reperfusion injury. J Neurochem. 2001；78（6）：1389-1399.

［136］Hussain SP，Amstad P，He P，Robles A，Lupold S，Kaneko I，Ichimiya M，Sengupta S，Mechanic L，Okamura S，Hofseth LJ，Moake M，Nagashima M，Forrester KS，Harris CC. p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis. Cancer Res. 2004；64（7）：2350-2356.

［137］Kuku I，Aydogdu I，Bayraktar N，Kaya E，Akyol O，Erkurt MA. Oxidant/antioxidant parameters and their relationship with medical treatment in multiple myeloma. Cell Biochem Funct. 2005；23（1）：47-50.