参考文献
1.Addolorato G,Leggio L,Hopf FW,et al.Novel therapeutic strategies for alcohol and drug addiction: focus on GABA,ion channels and transcranial magnetic stimulation.Neuropsychopharmacology,2012,37(1):163-177
2.Babu DK,Diaz A,Samikkannu T,et al.Upregulation of serotonin transporter by alcohol in human dendritic cells: possible implication in neuroimmune deregulation.Alcohol Clin Exp Res,2009,33(10):1731-1738
3.Blednov YA,Jung S,Alva H,Wallace D,et al.Deletion of the α1 or β2 subunit of GABA-A receptors reduces actions of alcohol and other drugs.J Pharmacol Exp Ther,2004,304(1):30-36
4.Blednov YA,Walker D,Alva H,et al.GABA A receptor α1 and β2 subunit null mutant mice:behavioral responses to ethanol.J Pharmacol Exp Ther,2003,305(1):854-863
5.Blevins T,Mirshahi T,Chandler LJ,et al.Effects of acute and chronic ethanol exposure on heteromeric N-methyl-D-aspartate receptors expressed in HEK 293 cells.J Neurochem,1997,69(6):2345-2354
6.Blum K,Noble EP,Sheridan PJ,et al.Allelic association of human dopamine D2 receptor gene in alcoholism.JAMA,1990,263(14):2055-2060
7.Bouza C,Angeles M,Munoz A,et al.Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review.Addiction,2004,99(7):811-828
8.Breese GR,Knapp D J,Moy SS.Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness,Neurosci.Biobehav Rev,2002,26(4):441-455
9.Canidate SS,Carnaby GD,Cook CL,et al.A Systematic Review of Naltrexone for Attenuating Alcohol Consumption in Women with Alcohol Use Disorders.Alcohol Clin Exp Res,2017,41(3):466-472
10.Cebere A,Cebers G,Liljequist S.Enhancement of NMDA-induced functional responses without concomitant NMDA receptor changes following chronic ethanol exposure in cerebellar granule cells.Naunyn Schmiedebergs Arch Pharmacol,1999,360(6),623-632
11.Chizh BA,Headley PM,Tzschentke TM.NMDA receptor antagonists as analgesics: focus on the NR2B subtype.Trends PharmacolSci,2001,22(12):636-642
12.Cowen MS,Lawrence AJ.The role of opioid- dopamine interactions in the induction and maintenance of ethanol consumption.Prog Neuropsychopharmacol Biol Psychiatry,1999,23(7):1171-1212
13.Dahchour A,De Witte P,Bolo N,et al.Central effects of acamprosate: part 1.Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats.Psychiatry Res,1998,82(2):107-114
14.Darstein MB,Landwehrmeyer GB,Feuerstein TJ.Changes in NMDA receptor subunit gene expression in the rat brain following withdrawal from forced long-term ethanol intake.Naunyn Schmiedebergs Arch Pharmacol,2000,361(2):206-213
15.Almeida RM,Rowlett JK,Cook JM,et al.GABA -A/α1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice.Psychopharmacology(Berl),2004,172(3):255-263
16.De Waele J-P,Gianoulakis C.Effects of single and repeated exposure to ethanol on hypothalamic h-endorphin and CRH release by the C57BL/6 and DBA/2 strains of mice.Neuroendocrinology,1993,57(4):700-709
17.El-Ghundi M,George SR,Drago J,et al.Westphal H and O’Dowd BF.Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior.Eur.J.Pharmacol,1998,353(2-3):149-158
18.Engleman EA,Keen EJ,Tilford SS,et al.Ethanol drinking reduces extracellular dopamine levels in the posterior ventral tegmental area of nondependent alcohol-preferring rats.Alcohol,2011,45(6):549-557
19.Engleman EA,McBride WJ,Wilber AA,et al.Reverse microdialysis of dopamine uptake inhibitor in the nucleus accumbens of alcohol-preferring rats: effects on dialysate dopamine levels and ethanol intake.Alcohol Clin Exp Res,2000,24(6):795-801
20.Ervin FR,Palmour RM,Young SN,et al.Voluntary consumption of beverage alcohol by vervet monkeys: Population screening,descriptive behavior and biochemical measures.Pharmacol Biochem Behav,1990,36(2):367-373
21.Froehlich JC,Zink RW,Li TK,et al.Analysis of heritability of hormonal responses to alcohol in twins: beta-endorphin as a potential biomarker of genetic risk for alcoholism.Alcohol Clin Exp Res,2000,24(3):265-277
22.Gelernter J,Kranzler H.D2 dopamine receptor gene(DRD2)allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype.Neuropsychopharmacology,1999,20(1):640-649
23.Gianoulakis C,Barcomb A.Effect of acute ethanol in vivo and in vitro on the h-endorphin system in the rat.Life Sci,1987,40(1):19-28
24.Gianoulakis C,Krishnan B,Thavumdayil J.Enhanced sensitivity of pituitary h-endorphin to ethanol in subjects at high risk of alcoholism.Arch Gen Psychiatry,1996,53(3):250-257
25.Gianoulakis C.Characterization of the effect of acute ethanol administration on the release of h-endorphin peptides by the rat hypothalamus.Eur J Pharmacol,1990,180(1):21-29
26.Gongwer MA,Murphy JM,McBride WJ,et al.Regional brain contents of serotonin,dopamine andtheir metabolites in the sekctively bred high and low-alcohol drinking lines of rats.Alcohol,1989,6(2):317-320
27.Grobin AC,Matthews DB,Devaud LL,et al.The role of GABAA receptors in the acute and chronic effects of ethanol.Psychopharmacology 1998,139(3):2-19
28.Heidbreder C and De Witte P.Ethanol differentially affects extracellular monoamines and GABA in the nucleus accumbens.Pharmacol.Biochem.Behav.,1993,46(2):477-481
29.Heyser CJ,Roberts AJ,Schulties G,et al.Central administration of an opiate antagonist decreases oral ethanol self-administration in rats.Alcohol Clin Exp Res,1999,23(9):1468-1476
30.Hodge CW,Haraguchi M,Erickson H,et al.Ventral tegmental microinjections of quinpirole decrease ethanol and sucrose-reinforcing responding.Alcohol Clin Exp Res,1993,17(5):370-375
31.Holman RIB,Snape BM.Effects of ethanol on 5-hydroxytryptamine release from rat corpus striatum in vivo.Alcohol,1985,2:249(1)-253
32.Hu XJ,Ticku MK.Functional characterization of a kindling-like model of ethanol withdrawal in cortical cultured neurons after chronic intermittent ethanol exposure.Brain Res,1997,767(2):228-234
33.Hyytia P.Involvement of mu-opioid receptors in alcohol drinking by alcohol-preferring AA rats.Pharmacol Biochem Behav,1993,45(3):697-701
34.Ikemoto S,McBride WJ,Murphy JM,et al.6-OHDA-lesions of the nucleus accumbens disrupt the acquisition but not the maintenance of ethanol consumption in the alcohol-preferring P line of rats.Alcohol Clin Exp Res,1997,21(6):1042-1046
35.Jamensky NT,Gianoulakis C.Comparison of the proopiomelanocortin and proenkephalin opioid peptide systems in brain regions of the alcohol-preferring 57BL/6 and alcohol-avoiding DBA/2 mice.Alcohol,1999,18(1):177-187
36.Katner SN,Weiss F.Neurochemical characteristics associated with ethanol preference in selected alcohol-preferring and-nonpreferring rats: a quantitative microdialysis study.Alcohol Clin Exp Res,2001,25(2):198-205
37.Kiefer F,Jahn H,Tarnaske T,et al.Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind,placebo-controlled study.Arch Gen Psychiatry,2003,60(1):92-99
38.Kiianmaa K,Nurmi M,Nykänen I,et al.Effect of ethanol on extracellular dopamine in the nucleus accumbens of alcohol-preferring AA and alcohol-avoiding ANA rats.Pharmacol Biochem Behav,1995,52(1):29-34
39.Kranzler HR,Armeli S,Feinn R,et al.Targeted naltrexone treatment moderates the relations between mood and drinking behavior among problem drinkers.J Consult Clin Psychol,2004,72(2):317-327
40.Kranzler HR,Tennen H,Armeli S,et al.Targeted naltrexone for problem drinkers.J Clin Psychopharmacol,2009,29(5):350-357
41.Kranzler HR,Van Kirk J.Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis.Alcohol Clin Exp Res,2001,25(9):1335-1341
42.Krishnan-Sarin S,Jing S-L,Kurtz DL,et al.The delta opioid receptor antagonist naltridole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference.Psychopharmacology,1995,120(2):177-185
43.Li X-W,Li T-K,Froehlich JC.Enhanced sensitivity of the nucleus accumbens proenkephalin system to alcohol in rats selectively bred for alcohol preference.Brain Res,1998,794(1):35-47
44.Malpass GE,Williams HL,McMillen BA.Effects of the non-competitive NMDA receptor antagonist memantine on the volitional consumption of ethanol by alcohol-preferring rats.Basic Clin Pharmacol Toxicol,2010,106(5):435-444
45.McBride WJ,Chernet E,Dyr W,et al.Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats.Alcohol,1993,10(5):387-390
46.Mihalek RM,Bowers BJ,Wehner JM,et al.GABAA-receptor δ subunit knockout mice have multiple defects in behavioral responses to ethanol.Alcohol Clin Exp Res,2001,25(12):1708-1718
47.Murphy JM,McBride WJ,Lumeng L,et al.Contents of monoamines in forebrain regions of alcohol-preferring P and -nonpreferring NP lines of tats.Pharmacol Biochem Behav,1987a,26(2):389-392
48.Murphy JM,McBride WJ.Lumeng L,Li T-K.Regional brain levels of monoamines in alcoholpreferring and nonpreferring lines of rats.Pharmacol Biochem Behav,1982,16(1): 145-149
49.Nagy,J.,Horváth,C.,Farkas,S.,et al.NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol-withdrawal in primary cultures of rat cortical neurons.Neurochem.Int.,2004,44(1):17-23
50.Platt DM,Duggan A,Spealman RD,et al.Contribution of α1 GABA A and α5 GABA A receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys.J Pharmacol Exp Ther,2008,313(3):658-667
51.Pohjalainen T,Rinne JO,Någren K,et al.The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers.Mol.Psychiatry,1998,3(3):256-260
52.Rasmussen DD,Boldt BM,Wilkinson CW,et al.Chronic daily ethanol and withdrawal: 3.Forebrain pro-opiomelanocortin gene expression and implications for dependence,relapse,and deprivation effect.Alcohol Clin Exp Res,2002,26(4):535-546
53.Rassnick S,L.Pulvirenti and G.F.Koob,SDZ-205,152.A novel dopamine receptor agonist,reduces oral ethanol self-administration in rats.Alcohol,1993,10(2):127-132
54.Rassnick S,Stinus L,Koob GF.The effects of 6-hydroxytryptamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat.Brain Res,1993,623(1):16-24
55.Roozen HG,de Waart R,van der Windt DA,et al.A systematic review of the effectiveness of naltrexone in the maintenance treatment of opioid and alcohol dependence.Eur Neuropsychopharmacol,2006,16(5):311-323
56.Rosner S,Leucht S,Lehert P,et al.Acamprosate supports abstinence,naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes.J Psychopharmacol,2008,22(1):11-23
57.Rossetti ZL,Melis F,Carboni S,et al.Dramatic depletion of mesolimbic extracellular dopamine after withdrawal from morphine,alcohol or cocaine: a common neurochemical substrate for drug dependence.Ann.N.Y.Acad Sci,1992,654(4):513-516
58.Rudolph JG,Walker DW,Iimuro Y,et al.NMDA receptor binding in adult rat brain after several chronic ethanol treatment protocols.Alcohol Clin Exp Res,1997,21(8):1508-1519
59.Sachs BD,Salahi AA,Caron MG.Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice.Neuropharmacology,2014,77(2):177-184
60.Samson HH,Hodge CW,Tolliver GA,et al.Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens.Brain Res Bull,1993,30(1-2):133-141
61.Schneider ML,Moore CF,Barr CS,et al.Moderate prenatal alcohol exposure and serotonin genotype interact to alter CNS serotonin function in rhesus monkey offspring.Alcohol Clin Exp Res,2011,35(5):912-920
62.Slawecki CJ,Hodge CW,Samson HH.Dopaminergic and opiate agonists and antagonists differentially decrease multiple schedule responding maintained by sucrose/ethanol and sucrose.Alcohol,1997,14(3):281-294
63.Smith AD,Weiss F.Ethanol exposure differentially alters central monoamine neurotransmission in alcohol-preferring versus-nonpreferring rats.J PharmacolExp Ther,1999,288(3):1223-1228
64.Srisurapanont M,Jarusuraisin N.Naltrexone for the treatment of alcoholism: a meta-analysis of randomized controlled trials.Int J Neuropsychopharmacol,2005(5),8:267-280
65.Stephens DN,Pistovcakova J,Worthing L,et al.Role of GABA A alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion,and a selective inverse agonist.Eur J Pharmacol,2005,526(1-3):240-250
66.Sullivan JM,Risacher SL,Normandin MD,et al.Imaging of alcohol-induced dopamine release in rats: preliminary findings with [(11)C]raclopride PET.Synapse,2011,65(9):929-937
67.Sundstrom-Poromaa I,Smith DH,Gong QH,et al.Hormonally regulated α4β2δ GABA A receptors are a target for alcohol.Nat Neurosci,2002,5(8):721-722
68.Trantham-Davidson H,Chandler LJ.Alcohol-induced alterations in dopamine modulation of prefrontal activity.Alcohol.2015,49(8):773-779
69.Tupala E,Hall H,Bergström K,et al.Dopamine D2/D3-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics.Mol Psychiatry,2001,6(3):261-267
70.Tupala E,Kuikka JT,Hall H,et al.Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography.NeuroImage,2001,14(1 Pt 1):87-94
71.Weiss F,Mitchiner M,Bloom FE,et al.Free-choice responding for ethanol versus water in alcohol preferring(P)and unselected Wistar rats is differentially is modified by naloxone,bromocriptine,and methylsergide.Psychopharmacology,1990,101(2):178-186
72.Weiss F,Parsons LH,Schulteis G,et al.Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats.J Neurosci,1996,16(10):3474-3485
73.Wills TA,Klug JR,Silberman Y,et al.GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.Proc Natl Acad Sci,2012,109(5):E278-E287
74.Winkler A,Roske I,Furkert J,et al.Effects of voluntary ethanol ingestion on the POMC gene expression in the rat pituitary and on the plasma beta-endorphin content.Alcohol Alcohol,1995,30(2):231-238
75.Wong DT,Threlkeld PG,Lumeng L,et al.Higher density of serotonin-1A receptors in the hippocampus and cerebral cortex of alcohol-preferring P rats.Life Sci,1990,46(3):231-235
76.Yim HJ,Gonzales RA.Ethanol-induced increases in dopamine extracellular concentration in rat nucleus accumbens are accounted for by increased release and not uptake inhibition.Alcohol,2000,22(2):107-115
77.Yim HJ,Robinson DL,White ML,et al.Dissociation between the time course of ethanol and extracellular dopamine concentrations in the nucleus accumbens after a single intraperitoneal injection.Alcohol Clin Exp Res,2000,24(6):781-788
78.Yoshimcto K,McBride WJ,Lumeng L,Li T-K.Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbons of HAD and LAD lines of rats.Alcohol Clin Exp Res,1992b,16(4):781-785
79.Yoshimoto K,Komura S.Reexamination of the relationship between alcohol preference and brain monoamines ininbred strains of mice including senescence-accelerated mice.Pharmacol Biochem Behav,1987,27(2):317-322
80.Ziauddeen H,Nathan PJ,Dodds C,et al.The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects.J Clin Pharmacol,2013,53(10):1078-1090